CAR-T Cell Therapy for the Treatment of ALL: Eradication Conditions and In Silico Experimentation

CAR-T Cell Therapy for the Treatment of ALL: Eradication Conditions and In Silico Experimentation

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In this paper, we explore the application of Chimeric Antigen Receptor (CAR) T cell therapy for the treatment of Acute Lymphocytic Leukaemia (ALL) by means of in silico experimentation, mathematical modelling through first-order Ordinary Differential Equations and nonlinear systems theory.By combining the latter with systems biology on cancer french manicure hydrangea evolution we were able to establish a sufficient condition on the therapy dose to ensure complete response.The latter is illustrated across multiple numerical simulations when comparing three mathematically formulated administration protocols with one of a phase 1 dose-escalation trial on CAR-T cells for the treatment of ALL on children and young adults.Therefore, both our analytical and in silico results are consistent with real-life scenarios.

Finally, our datrex life rafts research indicates that tumour cells growth rate and the killing efficacy of the therapy are key factors in the designing of personalised strategies for cancer treatment.